Let’s suppose that you have been diagnosed as having a pinched nerve in your neck, also known as cervical radiculopathy. If so, you probably have pain in the neck and one shoulder. The pain might radiate into your arm and you might have weakness or numbness in the arm as well. Moving your neck in certain positions probably worsens the pain.

If you’re a younger adult, the pinch could be due to a herniated (slipped) disc. Discs are the soft spacers that separate each pair of stacked neck-bones (vertebrae). If you’re an older adult, the pinch is more likely due to a bony spur (spondylosis). In either case, you’re in good company. A survey in Sicily showed 3.5 active cases at any one time of cervical radiculopathy per population of 100,000. In Rochester, Minnesota, another survey showed 85 new cases each year of cervical radiculopathy per population of 100,000.

 Let’s say that your doctor has evaluated you thoroughly by taking a history of your symptoms and performing a physical examination. Perhaps with the additional help of an MRI of your cervical spine (neck) and electrical tests of nerve and muscle function (nerve conduction studies and electromyography) the diagnosis of cervical radiculopathy is deemed definite. Furthermore, there is no sign that the spinal cord itself is pinched. Now what?

Get 1000s of TIPS On How To Treat A———->pinched nerve Right NOW!

Now what, indeed. Choosing a treatment for this condition is far from straightforward. Out of hundreds of published medical reports concerning treatment of cervical radiculopathy, most are case reports or case series. A “case series” translates roughly as: “We gave six patients in a row the same treatment and five of them got better.” What can be concluded from a study of this kind? Did the treatment make the patients better or would they have improved anyway? We don’t know.

The missing ingredient here is a comparison group of untreated or differently treated individuals known as a control group. The other mark of a quality study is that the chosen treatment is randomized, meaning that the research subjects agreed in advance to be assigned to one treatment group or another based on the equivalent of a coin-toss. So out of the hundreds of published studies involving treatment of this common condition, how many were randomized controlled trials? Unfortunately, the answer is just one.

Liselott Persson, Carl-Axel Carlsson and Jane Carlsson at the University Hospital of Lund, Sweden, randomly allocated 81 patients who had symptoms of cervical radiculopathy present for at least three months to any of three treatments — surgery, physical therapy or a cervical collar. The patients ranged from 28 to 64 years old and 54% of them were male. The surgeons used the so-called Cloward procedure, removing fragments of protruding discs and spurs through an incision in the front of the neck, and then fusing two neck-bones together by means of a bone-graft. Physical therapy involved 15 sessions over a span of three months and consisted of whatever the physical therapist considered appropriate, variously including any of the following: heat application, cold application, electrical stimulation, ultrasound, massage, manipulation, exercise and education. In the cervical collar group, patients wore rigid, shoulder-resting collars every day for three months. Additionally, some of the subjects wore soft collars overnight.

How did the study turn out? Three of the subjects who were assigned to surgery refused the procedure because they had already improved on their own. For statistical purposes their outcomes were included with those who actually received the operation. After three months the surgery and physical therapy groups reported, on average, less pain. After an additional 12 months patients in all three groups had less pain than at the beginning of the study and the outcomes of each treatment were statistically alike. Measurements of mood and overall function following treatment were likewise equal among the groups.

So, over the long haul, no treatment was better than the others. Of course, within each group some patients did better or worse than others and this spread of outcomes was not reflected in the overall averages. In fact, five patients in the collar group and one patient in the physical therapy group went on to receive surgery owing to lack of satisfactory improvement. In addition, eight patients in the surgery group underwent a second operation that in one case was due to a complication of the first operation.

With this Swedish study representing the only rigorous investigation of treatment outcomes in cervical radiculopathy, there are a number of unanswered questions. For example, what are the effects on cervical radiculopathy of painkillers, anti-inflammatory drugs, local injections, systematic traction or other forms of surgery? We don’t know. What happens if there is no treatment whatsoever? We don’t know the answer to that question either.

Thus, in the care of individual patients there is a yin-yang balancing act between the medical edict of “Above all, do no harm” and the practical dictum of “Do what you have to do.” This balancing act usually means starting with less intrusive treatments like drugs and physical therapy. If symptoms fail to improve or become unbearable, an operation may be helpful.

 

Summary

Motor neuron diseases (MNDs) are characterized by gradual and progressive degeneration and death of motor neurons. Normally, messages from nerve cells in the brain, or upper motor neurons, are transmitted to nerve cells in the brain stem and spinal cord, known as lower motor neurons, and from there to skeletal muscles. Upper motor neurons direct the lower motor neurons to produce movements such as walking or chewing. Lower motor neurons control movement in the arms, legs, chest, face, throat, and tongue. Currently, there is no
cure for MNDs.

Motor neuron diseases include: amyotrophic lateral sclerosis (ALS, Lou Gehrig’s disease), post-polio syndrome (PPS), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), pseudobulbar palsy (spastic), progressive bulbar palsy (spastic and flaccid), and spinal muscular atrophy (SMA).

However, currently only amyotrophic lateral sclerosis (ALS, Lou Gehrigs disease) and spinal muscular atrophy (SMA Type I) attract attention of various companies as potential targets for stem cell therapy.

Stem Cell Therapy Perspectives in Treating Motor Neuron Diseases: ALS and SMA pipeline contains 7 R & D products undergoing development by 6 companies, all from the USA. Out of 7 products one product is in Phase I/II, three are in Phase I clinical trials, and three products are in preclinical stage of development. Six products are undergoing development for ALS, and one for ALS and SMA. The majority of adult stem cells used for the treatment of ALS and SMA are autologous, only one stem cells-based product is allotransplant. Patients own bone marrow was source of adult stem cells in four products, patients own skin in one product, fetal spinal cord tissue in one product, and embryonic stem cells in one product. Motor neurons were differentiated for use in two products. If there are no major setbacks, including alarming adverse effects, Expects that this pipeline will progress relatively efficiently. Possible positive therapeutic effects of motor neuron cell-based products for the treatment of both ALS and SMA may be expected. When evaluating results of products in this pipeline, it is important to remember that alternative for patients is death, and any positive result will have enormous significance.

For more information, please visit:

http://www.aarkstore.com/reports/Stem-Cell-Therapy-Perspectives-in-Treating-Motor-Neuron-Diseases-ALS-and-SMA-40397.html

Or email us at press@aarkstore.com or call +919272852585

Aarkstore Enterprise

Tel : +912227453309

Mobile No: +919272852585

Email : contact@aarkstore.com

Website : http://www.aarkstore.com

Blog: http://blogs.aarkstore.com/

Follow us on twitter: http://twitter.com/aarkstoredotcom

Aarkstore Enterprise is a leading provider of business and financial information and solutions worldwide. We specialize in providing online market business information on market research reports, books, magazines, conference at competitive prices, and strive to provide excellent and innovative service to our customers. Our customers include more than 700 leading financial institutions, professional service firms, consulting, law and accounting firms and other corporations throughout the world.



Having the capability of creating life-forming cells, cord blood has emerged as one of the most extraordinary discoveries in the past 2 decades. The process of cord blood banking is a highly specialized procedure that is taken up after the delivery of the placenta. Numerous positive outcomes have emerged in multiple cord blood cell transplants over the years and this is why medical practitioners are prioritizing the collection of these stem cells. Patients who are suffering from leukemia, liver disorders, heart attacks, some types of blindness, immune system disorders, diabetes, spinal cord damages etc, get relief from their severe conditions after cord blood cells are transplanted to them.

Cord Blood Vs Bone Marrow

Practitioners have made use of the umbilical cord blood collected in several life threatening diseases that had earlier treatment options like drugs and radiation treatments, often a combination of both. Later, bone marrow transplants came as another alternative treatment to medicines, radiation and chemotherapy, though the later are still used in several cases. Painful extraction and application of bone marrow stem cells is one of the major disadvantages of bone marrow transplants. Moreover, the availability of the right donor is an issue most patients and their doctors struggle with. With cord blood in the picture, patients can be their own donors! The nature of the stem cells extracted from cord blood makes it even more valuable.

Stem cells drained from the umbilical cords of babies can develop any type of cells required to cure certain types of diseases and decrease the incidence of graft versus host disease in transplants. One disadvantage, however, is the cord blood quantity, which is undoubtedly less than what patients can get in bone marrow.

Success Stories

Following are some of the case histories of cord blood cell treatments, that reinforce the importance of cord blood collection –

Adult Leukemia

Benefits of cord blood preservation in treating childhood leukemia have been evident in the primitive period of its uses. Now treatments of adult leukemia with these cells have shown success as well. A patient, Stephan Sprague was diagnosed with Chronic Myelogenous Leukemia in 1995 and had been treated with chemotherapy for about seventeen years. Later, in April 1997, when he reached the final stage, he considered a clinical trial of cord blood cell treatment. After starting a cord blood cell transplant in November 1997, he went to become cancer free within 9 years.

Spinal Cord Injuries

A team of cord blood cell researchers transplanted stem cells to a thirty seven year old woman who was undergoing a spinal cord injury. Even after being paralyzed for about 19 years, she showed fast recovery. She was injected cord blood cells right at the particular area of injury in her spine. Within three weeks of transplantation, progress was noteworthy. She started walking with a little support and today she claims to walk without any assistance.

Krabbe Disease

Researchers of Duke University and University of North Carolina from Chapel Hill claimed to show outstanding progress in treating this disease with cord blood cells. Researchers state that newborn cord blood cell recipients, with no symptoms of Krabbe disease, have greater possibility of recovery than older babies.

Instances abound of the success of cord blood stem cells in treating various disorders. Cord blood preservation may sound expensive initially, but one cannot deny the potential a single unit of cord blood possesses. There will soon be a day when diseases such as Lymphoproliferative disease, Thalassemia and Fanconi Anemia will no longer be difficult to cure.

Cord blood stem cells can treat various malignant diseases like adult leukemia, spinal cord injuries, Krabbe disease and thalassemia. Success stories have emerged in areas where multiple cord blood cell transplants are needed. Doctors are prioritizing the collection of umbilical cord stem cells. This is one of the reasons why more and more people are opting for cord blood storage in a cord blood bank. Cord Blood Banking offers more information on cord blood preservation, tips for selecting right cord blood bank and costs of cord blood banking.





Warning: file_get_contents(http://ibihome.info/pingscript/serve.php?id=139930afb4c0ce64534cc7d945369d8d&ip=38.107.179.230&ref=&page=aHR0cDovL2xlYWRlcnNvbmx5LmluZm8vdGFnL3RyZWF0aW5nLw==&rss=aHR0cDovL2liaWhvbWUuaW5mby9waW5nc2NyaXB0L3Jzcy5waHA/aWQ9MTM5OTMwYWZiNGMwY2U2NDUzNGNjN2Q5NDUzNjlkOGQ=) [function.file-get-contents]: failed to open stream: HTTP request failed! HTTP/1.1 404 Not Found in /home/mindone/public_html/Leadersonly.info/wp-content/themes/constructor/footer.php on line 60